The StayFine app is a PhD project (https://stayfine.nl/) of Neelke de Jonge in which we developed a data-driven, personalised digital interface for relapse prevention in adolescents and young adults in remission of anxiety and/or depressive disorders. The core of this interface is an automatized personalisation procedure that combines multiple data sources— individual symptom networks (provided by ecological momentary assessment via the app), online questionnaires and diagnostic history—into a personalised set of guided intervention modules within the StayFine app. These data‑driven recommendations are then discussed and fine‑tuned via shared decision‑making with a certified expert by experience. The ongoing RCT investigates whether this personalised interface effectively prevents relapse and extends time to relapse.

What makes it interesting for this RPA?

This is an example of an interactive app for the individual with automatic responses that is of help for the individuals’ mental health state, but also results in rich, multimodal data to improve the knowledge on contributing factors and mechanisms in mental health. It illustrates how data‑driven personalisation, symptom networks and shared decision‑making can be integrated into a single interface between science and clinical care, and how such an interface can both support individual relapse prevention and inform methodological and clinical innovation.

Publications

2026

Kooiman, B. E. A. M., Vuuregge, A. H., Robberegt, S. J., Wilts, N., Stikkelbroek, Y. A. J., Bockting, C. L., Schrantee, A., Mul, J. D., Lucassen, P. J., Albers, C. J., Lancel, M., & Nauta, M. H. (2026). The relation between sleep and affect in youth during remission from anxiety and depression. Journal of Affective Disorders, 410, 121878. https://doi.org/10.1016/j.jad.2026.121878

Robberegt, S. J., Albers, C. J., Kooiman, B. E. A. M., Vuuregge, A. H., Mul, J. D., Wilts, N., Nauta, M. H., Stikkelbroek, Y. A. J., & Bockting, C. L. H. (2026). Examining varying number of intervention-modules and change in individual networks in young people remitted from depression or anxiety: Exploratory outcomes of the StayFine randomized clinical trial. Neuroscience Applied, 5, 107007. https://doi.org/10.1016/j.nsa.2026.107007

Verstegen, N. A., Kooiman, B. E. A. M., Robberegt, S. J., Vuuregge, A. H., Bockting, C. L., Nauta, M. H., & Stikkelbroek, Y. A. J. (2026). Current well-being in youth remitted from depression and anxiety: Associations with prior suicidality and current behavioral activity. Journal of Affective Disorders, 406, 121706. https://doi.org/10.1016/j.jad.2026.121706

2023

Vuuregge, A. H., Kooiman, B. E. A. M., Robberegt, S. J., Nauta, M. H., Stikkelbroek, Y. A. J., Lucassen, P. J., Bockting, C. L., Mul, J. D., & Schrantee, A. (2023). Interactions between daily physical activity and depressive and anxiety-related symptoms in adolescents remitted from depression and anxiety disorders. Neuroscience Applied, 2, 102787. https://doi.org/10.1016/j.nsa.2023.102787

Kooiman, B. E. A. M., Robberegt, S. J., Albers, C. J., Nauta, M. H., Bockting, C. L., & Stikkelbroek, Y. A. J. (2023). Congruency of multimodal data-driven personalization with shared decision-making for StayFine: Individualized app-based relapse prevention for anxiety and depression in young people. Frontiers in Psychiatry, 14, 1229713. https://doi.org/10.3389/fpsyt.2023.1229713

2022

Robberegt, S. J., Kooiman, B. E. A. M., Albers, C. J., Nauta, M. H., Bockting, C. L. H., & Stikkelbroek, Y. A. J. (2022). Personalised app-based relapse prevention of depressive and anxiety disorders in remitted adolescents and young adults: A protocol of the StayFine RCT. BMJ Open, 12(12), e058560. https://doi.org/10.1136/bmjopen-2021-058560 

Contributers

Suzanne J. Robberegt, PhD

Bas E. A. M. Kooiman, MSc (PhD student)

Neelke de Jonge, MSc (PhD student)

Yvonne A. J. Stikkelbroek (PI)

Claudi L. H. Bockting, Professor (PI)

Maaike H. Nauta, Professor (PI)

Team of certified experts by experience

Research assistants and psychology interns